Nonmyeloablative conditioning regimens are the logical andsafer approach for both autologous and allogeneic hematopoieticstem cell transplantation for autoimmune diseases.在自体和异基因造血干细胞移植治疗自身免疫性疾病中,非清髓的预处理方案是合理的、安全的途径。In the animal model reported by Flierman and colleagues,stable long-term high-percentage donor chimerism(>95%)without clinical graft-versus-host disease(GVHD)was achievedwith a nonmyeloablative stem cell transplantation(NST)regimenof reduced intensity total body irradiation(TBI)and costimulato-ry blockade with anti-CD40L.The result was durable remissionof collagen-induced arthritis(CIA).Consequent with other re-ports,this animal preclinical study adds support for use of allo-geneic NST for autoimmune disorders.CIA is an environmentallyinduced(initiated by immunizing the immune system to collagen)autoimmune disease.This paper and other recent publicationshave shown that allogeneic NST-induced mixed chimerism resultsin remission of both environmentally ind...

从动物实验到临床非清髓的异基因骨髓移植治疗自身免疫性疾病.caj